A recent study in the journal, Proceedings of the National Academy of Sciences, has cited research into a synthetic molecule, sulfate monosaccharide that can block T-cell signals in the body. While their research is centered on the allergen response that triggers an asthma attack, this synthetic molecule could one day have the potential to reduce or inhibit the inflammation response triggered in rosacea.
This molecule when tested in mice was able to lessen the systemic response of inflammation airway constriction and mucus production associated with an asthma attack. The synthetic sulfate monosaccharide interrupted the interaction of a T-cell signally protein called chemokine CCL20 and a molecule called heparin sulfate that stimulates the action of the T-cell response. When the T-cell and heparin sulfate response was blocked, the body’s natural inflammation response to the allergen is not triggered.
In theory by blocking the immune system triggered response to the allergen that stimulates inflammation, we should be able to one day block the inflammation and redness response triggered by a rosacea flare. While research continues to speculate on possible ways to control symptoms and this may be a possible aid in treatment in 10 to 15 years in the meantime there are other solutions that we may employ today to control this immune system response. The researchers working with Rosacea-Ltd have found that controlling and monitoring the acidity levels in the body can balance the immune system response. Maintaining a more alkaline pH levels in the body can help regulate the interaction of the T-cell response and thus reduce inflammation and skin redness.